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- Title
Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities.
- Authors
Santos, Michelli; Da Silva Santos, Felipe; Ferraz, Ariane; Andrade, Jéssica; Silva Herrera, Karina; Lima, William; Sales Pereira, Lailah; Da Silva, Marina; Perez Villar, José; De Magalhães, José; Taranto, Alex; Dos Santos, Luciana; Pinheiro Soares-Martins, Jamária; Siqueira Ferreira, Jaqueline
- Abstract
Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. The variety of biological properties of chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search of more powerful and efficient drugs to several infectious diseases' treatment. Objective: The purpose of this work was to evaluate the potential antibacterial, antifungal, and anti-dengue virus (DENV) of new ten triazole chalcones. Materials and Methods: Triazole chalcones were used to determine its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) species, and anti-Candida activity (Candida albicans) by the broth microdilution assay. The anti-DENV activity was evaluated by cell viability quantification after viral infection by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Results: Although Triazole chalcones have shown a low cytotoxicity concentration (with CC50of 47.21–192.51 μg/mL), these compounds did not exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria, C. albicans neither DENV, even in the highest concentration tested. Triazole chalcones had no activity against all tested microorganisms, except for Gram-positive S. epidermidis bacteria when a poor antimicrobial effect was observed (125 μg/mL). Conclusion: The results suggest that triazole chalcones investigated in this study are not promising antimicrobial agents.
- Subjects
CHALCONES; TRIAZOLES; ANTIBACTERIAL agents; GRAM-positive bacteria; DRUG resistance in bacteria
- Publication
Journal of Pharmaceutical Negative Results, 2018, Vol 9, Issue 1, p39
- ISSN
0976-9234
- Publication type
Article
- DOI
10.4103/jpnr.JPNR_2_18