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- Title
A Rare Case of Mosaic Unbalanced Non-Robertsonian Translocation Involving Chromosomes 15 and 22 with Congenital Abnormalities in Monozygotic Twins.
- Authors
Atli, Emine I.; Atli, Engin; Yalcintepe, Sinem; Gurkan, Hakan
- Abstract
Balanced de novo non-robertsonian translocations (non-RTs), which involve acrocentric chromosomes, are rare findings in clinical cytogenetics and may be associated with an abnormal phenotype. These translocations, detected by conventional karyotyping, are found in approximately 1:1,000 neonates. In most of these cases, one of the parents carries the same translocation. In this study, we report a rare non-RT involving chromosomes 15 and 22 defined as 45,XX,-22,der(15;22)t(15;22)/46,XX,der(15)t(15;22),der(22). To our knowledge, this is the first report of a non-RT t(15;22) with these breakpoints.
- Publication
Molecular Syndromology, 2019, Vol 10, Issue 6, p320
- ISSN
1661-8769
- Publication type
Article
- DOI
10.1159/000505004