We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Impact of Nosocomial Infection on in-Hospital Mortality Rate in Adult Patients Under Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery.
- Authors
Li, Xiyuan; Wang, Xiaomeng; Wang, Liangshan; Li, Chenglong; Hao, Xing; Du, Zhongtao; Xie, Haixiu; Yang, Feng; Wang, Hong; Hou, Xiaotong
- Abstract
Objective: There was no consensus on the impact of nosocomial infection on In-hospital mortality rate in patients receiving ECMO. This study aimed to investigate the impact of nosocomial infection (NI) on In-hospital mortality rate in adult patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) after cardiac surgery. Materials and Methods: This retrospective study included 503 adult patients who underwent VA-ECMO after cardiac surgery. The impact of time-dependent NIs on In-hospital mortality rate within 28 days of ECMO initiation was investigated using a Cox regression model. The cumulative incidence function for death was compared between patients with NIs and those without NIs using a competing risk model. Results: Within 28 days after ECMO initiation, 206 (41.0%) patients developed NIs, and 220 (43.7%) patients died. The prevalence rates of NIs were 27.8% and 20.3% during and after ECMO therapy, respectively. The incidence rates of NIs during and after ECMO therapy were 49‰ and 25‰, respectively. Time-dependent NI was an independent risk factor for predicting death (hazard ratio = 1.05, 95% confidence interval = 1.00– 1.11). The cumulative incidence of death in patients with NI was significantly higher than that in patients without NI at each time point within 28 days of ECMO initiation. (Z = 5.816, P = 0.0159). Conclusion: NI was a common complication in adult patients who received VA-ECMO after cardiac surgery, and time-dependent NI was an independent risk factor for predicting mortality in these patients. Using a competing risk model, we confirmed that NIs increased the risk of In-hospital mortality rate in these patients.
- Subjects
EXTRACORPOREAL membrane oxygenation; NOSOCOMIAL infections; HOSPITAL mortality; CARDIAC surgery; DEATH rate; MORTALITY risk factors
- Publication
Infection & Drug Resistance, 2023, Vol 16, p4189
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S390599