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- Title
Aspidiata E, a New Spirostanol Saponin From Aspidistra triradiata and its Cytotoxic Activity.
- Authors
Le, Hien Bich Thi; Tran, Van Anh Thi; Nguyen, Hien Minh; Nguyen, Linh Thuy Khanh; Ho, Duc Viet; Nguyen, Hoai Thi
- Abstract
Aspidiata E (1), a new spirostanol saponin {(22 S *,25 R*)-1 β,3 β,4 β,5 β,6 β -pentahydroxyspirostan-2 β -yl β -D-xylopyranoside), together with 2 known compounds, (22 S *,25 R*)-spirost-5-ene-3 β -yl O - α- L-rhamnopyranosyl-(1→2)- O -[ O - α -L-rhamnopyranosyl-(1→5)- α -L-arabinofuranosyl-(1→4)]- β -D-glucopyranoside (2), and (22 S*)-16-[(β -D - glucopyranosyl)oxy]-1 β,3 β, 22-trihydroxycholest-5-en-1 β- yl α -L-rhamnopyranoside (3), were isolated from Aspidistra triradiata. Their structures were determined by NMR spectroscopic and high resolution electrospray ionisation mass spectrometry analysis and by comparison with published data. Compound 2 revealed strong cytotoxic potential against MCF7, HepG2, SK-LU-1, and HT-29 cancer cell lines with IC50 values ranging from 0.28 to 0.81 µM. In contrast, compound 1 showed a weak inhibitory effect on MCF7, HepG2, and HT-29 cell lines, with IC50 values within the range of 68.85 to 84.19 µM. All compounds 1 - 3 were discovered for the first time in the genus Aspidistra.
- Subjects
SAPONINS; ELECTROSPRAY ionization mass spectrometry; CELL lines
- Publication
Natural Product Communications, 2023, Vol 18, Issue 6, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X231179412