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- Title
Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians.
- Authors
Myles, Sean; Hradetzky, Eva; Engelken, Johannes; Lao, Oscar; Nürnberg, Peter; Trent, Ronald J; Wang, Xingyu; Kayser, Manfred; Stoneking, Mark
- Abstract
The prevalence of non-insulin-dependent diabetes mellitus (type II diabetes) in Polynesia is among the highest recorded worldwide and is substantially higher than in neighboring human populations. Such large differences in the frequency of a phenotype between populations may be explained by large allele frequency differences between populations in genes associated with the phenotype. To identify genes that may explain the high between-population variation in type II diabetes prevalence in the Pacific, we determined the frequency of 10 type II diabetes-associated alleles in 23 Polynesians, 23 highland New Guineans and 19 Han Chinese, calculated population-pairwise Fst values for each allele and compared these values to the distribution of Fst values from ∼100 000 SNPs from the same populations. The susceptibility allele in the PPARGC1A gene is at a frequency of 0.717 in Polynesians, 0.368 in Chinese but is absent in the New Guineans. The striking frequency difference between Polynesians and New Guineans is highly unusual (Fst=0.703, P=0.007) and we therefore suggest that this allele may play a role in the large difference in type II diabetes prevalence between Polynesians and neighboring populations.European Journal of Human Genetics (2007) 15, 584–589. doi:10.1038/sj.ejhg.5201793; published online 28 February 2007
- Subjects
POLYNESIA; TYPE 2 diabetes; DIABETES; GENES; PHENOTYPES
- Publication
European Journal of Human Genetics, 2007, Vol 15, Issue 5, p584
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201793