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- Title
Central retinal thickness following panretinal photocoagulation using a multispot semi‐automated pattern‐scanning laser to treat ischaemic diabetic retinopathy: Treatment in one session compared with four monthly sessions.
- Authors
Gabrielle, Pierre‐Henry; Massin, Pascale; Kodjikian, Laurent; Erginay, Ali; Pallot, Charlotte; Jonval, Lysiane; Soudry, Agnès; Couturier, Aude; Vardanian‐Vartin, Cristina; Bron, Alain M.; Creuzot‐Garcher, Catherine
- Abstract
Purpose: To compare central retinal thickness (CRT) after panretinal photocoagulation (PRP) with a multispot semi‐automated PAttern‐SCAnning Laser (PASCAL) in one session (SS‐PRP) versus four monthly sessions (MS‐PRP) in diabetic retinopathy. Methods: Multicentre, prospective, randomized, single‐blinded, controlled trial evaluating the noninferiority of SS‐PRP versus MS‐PRP for CRT measured with macular spectral‐domain optical coherence tomography (SD‐OCT), with a 9‐month follow‐up in patients presenting severe nonproliferative diabetic retinopathy (DR) or mild proliferative DR without macular oedema (ME) at baseline. Results: Ninety‐seven eyes of 97 participants with a mean age of 57.0 ± 14.2 years were included. The mean change of CRT from baseline to 9 months was not statistically different in SS‐PRP or in MS‐PRP: +16.9 ± 28.3 μm versus +24.7 ± 31.8 μm, respectively (p = 0.224). The variation in mean best‐corrected visual acuity (BCVA) from baseline to 9 months was similar in both groups: −1.1 ± 6.5 letters versus −0.6 ± 6.2 letters (p = 0.684). The number of patients with stabilization of DR was not statistically different between the two groups. No severe complication was recorded in either group. Conclusion: This study showed the noninferiority of PRP performed in one session versus four monthly sessions with a PASCAL concerning central retinal thickness for treating mild proliferative or severe nonproliferative DR without ME at baseline.
- Subjects
LASER photocoagulation; PASCAL, Blaise, 1623-1662; DIABETIC retinopathy; THERAPEUTICS; LIGHT coagulation; OPTICAL coherence tomography; LASERS
- Publication
Acta Ophthalmologica (1755375X), 2019, Vol 97, Issue 5, pe680
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.14002