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- Title
High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre.
- Authors
Boehnke, C.; Reuter, U.; Flach, U.; Schuh-Hofer, S.; Einhaupl, K.M.; Arnold, G.
- Abstract
The aim of this study was to investigate the efficacy of riboflavin for the prevention of migraine. An open label study was performed in a specialized outpatient clinic. Patients received 400 mg riboflavin capsules per day. Headache frequency, duration, intensity and the use of abortive drugs were recorded at baseline and 3 and 6 months after treatment. Headache frequency was significantly reduced from 4 days/month at baseline to 2 days/month after 3 and 6 months ( P < 0.05). The use of abortive drugs decreased from 7 units/month to 4.5 units/month after 3 and 6 months of treatment ( P < 0.05). In contrast, headache hours and headache intensity did not change significantly. We could demonstrate a significant reduction of headache frequency following riboflavin treatment. In addition, the number of abortive anti-migraine tablets was reduced. In line with previous studies our findings show that riboflavin is a safe and well-tolerated alternative in migraine prophylaxis.
- Subjects
VITAMIN B2; MIGRAINE; HEADACHE; DRUGS; OUTPATIENT medical care; MEDICAL care
- Publication
European Journal of Neurology, 2004, Vol 11, Issue 7, p475
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/j.1468-1331.2004.00813.x