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- Title
La frecuencia del genotipo 1 del virus de hepatitis C no ha variado en Venezuela.
- Authors
del Pilar Fortes, María; Trómpiz, Aleidy; Canónico, Yeily; Vargas-Lovelle, Berta; Machado, Irma V.
- Abstract
Changes in hepatitis C virus (HCV) genotypes distribution and frequency have been reported in some countries including Venezuela. We analyze the frequency of the HCV genotypes in our country evaluating a possible distribution change at national level. Eight hundred and nine sera of patients infected by HCV coming from Caracas and of 11 Venezuelan states were investigated by means of PCR-RFLP. In 527 sera we identified the genotype 1 (65.1%), 34.4% showed genotype 2 while genotypes 3, 4 nd 5 were highly uncommon. Of 316 patients infected with genotype 1, 56% showed levels of HCV RNA < 600.000 IU/mL and 44% levels superior to this cut-off. We demonstrate that the distribution and frequency of HCV genotypes remains unaffected in Venezuela, with prevalence of the genotype 1b and near the half with high viral load.
- Subjects
VENEZUELA; MEDICAL research; HEPATITIS C virus; GENETIC polymorphisms; GENETIC research; LIVER diseases; BLOOD plasma; VIRAL hepatitis; NUCLEIC acids
- Publication
Revista Colombiana de Gastroenterología, 2009, Vol 24, Issue 3, p256
- ISSN
0120-9957
- Publication type
Article