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- Title
Association between nocturia and serum albumin in the U.S. adults from NHANES 2005–2012.
- Authors
Jia, Yangtao; Yang, Fangzheng; Dong, Xinke; Zhou, Libin; Long, Huimin
- Abstract
Background: Nocturia, a prevalent chronic condition, impacts individuals' quality of life but remains underexplored. This study aimed to assess the association between serum albumin levels and nocturia. Methods: Based on the analysis of the National Health and Nutrition Examination Survey (NHANES) database (2005–2012), our study included a total of 6345 adults (≥20 years old). Nocturia was defined as ≥2 nocturnal voiding episodes. Logistic regression and smooth curve fitting analyzed the linear and nonlinear correlations between serum albumin and nocturia, with subgroup analysis. Results: Among 6345 participants, 1821 (28.7%) experienced nocturia. Logistic regression analysis revealed a linear negative correlation between serum albumin and nocturia risk (OR = 0.9549, 95% CI = 0.9280 ~ 0.9827, P = 0.002). Even after quartile division of serum albumin concentration, this correlation persisted within each group, and a smooth curve fitting validated the nonlinear negative correlation between the two. Subgroup analysis further demonstrated significant impacts of body mass index (BMI), alcohol consumption, and age on this association. Conclusion: This cross-sectional study indicated that higher serum albumin levels were associated with a reduced risk of nocturia in U.S. adults aged 20 and older, highlighting the importance of serum albumin in the prevention and treatment of nocturia and providing clinical guidance.
- Subjects
HEALTH &; Nutrition Examination Survey; SERUM albumin; LOGISTIC regression analysis; BODY mass index; NOCTURIA
- Publication
PLoS ONE, 2024, Vol 19, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0308980