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- Title
Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the Literature.
- Authors
John, Alexius; Spain, Lavinia; Hamid, Anis A.
- Abstract
Non-clear cell renal cell carcinoma (nccRCC) is an entity comprised of a heterogeneous constellation of RCC subtypes. Genomic profiling has broadened our understanding of molecular pathogenic mechanisms unique to individual nccRCC subtypes. To date, clinical trials evaluating the use of immunotherapies and targeted therapies have predominantly been conducted in patients with clear cell histology. A comprehensive review of the literature has been undertaken in order to describe molecular pathogenic mechanisms pertaining to each nccRCC subtype, and concisely summarise findings from therapeutic trials conducted in the nccRCC space.
- Subjects
RENAL cell carcinoma; IMMUNOTHERAPY; CLINICAL trials; THERAPEUTICS; MEDICAL care; MEDICAL personnel
- Publication
Current Oncology, 2023, Vol 30, Issue 1, p923
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30010070