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- Title
Transition-Metal-Free BF<sub>3</sub>-Mediated Oxidative and Non-Oxidative Cross-Coupling of Pyridines.
- Authors
Chen, Quan; León, Thierry; Knochel, Paul
- Abstract
We report a BF3-mediated direct alkynylation of pyridines at C(2) by using a variety of alkynyllithium reagents (oxidative cross-coupling). Moreover, we have developed a novel transition-metal-free cross-coupling method between alkylmagnesium reagents and 4-substituted pyridines, such as isonicotinonitrile and 4-chloropyridine, by employing BF3⋅OEt2 as a promoter. The combination of these methods enabled us to efficiently prepare a range of di-, tri-, and tetrasubstituted pyridines.
- Subjects
TRANSITION metals; PYRIDINE; LITHIUM; MAGNESIUM; CHLORANIL
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 33, p8746
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201400750