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- Title
Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development.
- Authors
Wang, Chia‐Hung; Li, Shiou‐Ting; Lin, Tzu‐Lung; Cheng, Yang‐Yu; Sun, Tsung‐Hsien; Wang, Jin‐Town; Cheng, Ting‐Jen R.; Mong, Kwok Kong Tony; Wong, Chi‐Huey; Wu, Chung‐Yi
- Abstract
Sweetening the deal: N. meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide–protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.
- Subjects
OLIGOSACCHARIDE synthesis; CARBOHYDRATES; NEISSERIA meningitidis; CARRIER proteins; ANTIGEN presenting cells; THERAPEUTICS
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 35, p9157
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201302540