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- Title
Similarities and differences in structure, expression, and functions of VLDLR and ApoER2.
- Authors
Reddy, Sunil S.; Connor, Teal E.; Weeber, Edwin J.; Rebeck, William
- Abstract
Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.
- Subjects
LOW density lipoproteins; APOLIPOPROTEIN E; EXTRACELLULAR matrix; NERVOUS system; EXTRACELLULAR matrix proteins
- Publication
Molecular Neurodegeneration, 2011, Vol 6, Issue 1, p30
- ISSN
1750-1326
- Publication type
Article
- DOI
10.1186/1750-1326-6-30