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- Title
Clinical course of breast cancer patients with osseous metastasis treated with combination chemotherapy.
- Authors
Scheid, Vicky; Buzdar, Aman U.; Smith, Terry L.; Hortobagyi, Gabriel N.; Scheid, V; Buzdar, A U; Smith, T L; Hortobagyi, G N
- Abstract
Between July 1973 and December 1979, 1171 patients with metastatic breast cancer were treated with doxorubicin-containing chemotherapy. Of those patients, 195 had osseous metastases only. Upon initial diagnosis, 48% had osteolytic metastases; 13% had osteoblastic metastases; 38% had mixed metastases; and 1% had diffuse osteoporosis without any obvious bone destruction. The most common sites of involvement were the dorsal spine (62%), lumbosacral spine (72%), and pelvis (79%). Objective response to chemotherapy was observed in 59% of patients; complete responses were noted in 7%, and partial responses in 52%. The median survival was 28 months (range, 1-118 months). The median time lapse between the start of chemotherapy and disease progression was 14 months (range, 1-109 months). In 32 patients who responded to the treatment, chemotherapy was discontinued after 2 years, and their median duration of continued remission at 39 and 75 months after the completion of therapy. The incidence of pathological fractures was 57%; the most common sites were the spine, which sustained compression fractures, and the ribs. The incidences of hypercalcemia and spinal cord compression due to metastases were 19% and 10%, respectively.
- Publication
Cancer (0008543X), 1986, Vol 58, Issue 12, p2589
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19861215)58:12<2589::AID-CNCR2820581206>3.0.CO;2-O