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- Title
Do Oral Carotenoids Protect Human Skin Against Ultraviolet Erythema, Psoralen Phototoxicity, and Ultraviolet-Induced DNA Damage?
- Authors
Wolf, Chris; Steiner, Andreas; Hönigsmann, Herbert
- Abstract
This study was performed in order to (1) assess the magnitude of a possible protective effect of oral carotenoids on ultraviolet B (UVB)-, ultraviolet A (UVA)-, and psoralen ultraviolet A (PUVA)-induced erythema in human skin and (2) to evaluate whether the postulated prevention of skin cancer by prophylactic administration of carotenoids is based on a decrease in UVB-induced DNA damage. Twenty-three healthy volunteers received oral carotenoids (150 mg/day) for 4 weeks. Serum levels were quantitated, and ranged from 390 to 1710 μg/dl. Before and after carotenoid administration, the UVA- and UVB-MEDs and the PUVA-MPD were determined by standard phototesting. DNA damage was assessed by autoradiographical measurement of unscheduled DNA synthesis (UDS) following UVB exposure before and after treatment. No statistically significant carotenoid-dependent protection was found against UVA, UVB, and PUVA erythema by comparing the pre- and postcarotenoid erythema doses. Also at the DNA level there was no indication of a protective effect that could be detected with the methods employed: the amount of UVB-induced UDS was not decreased after carotenoid treatment. We conclude that (1) carotenoids do not reduce UVB-, UVA-, or PUVA-induced erythema in human skin; that (2) reactive oxygen species may not he involved in PUVA-erythema production or, alternatively, carotenoids may not quench these radicals sufficiently in vivo; and that (3) carotenoid protection against UVB-induced carcinogenesis does not operate by reducing the number of mutagenic lesions in DNA.
- Subjects
SKIN cancer; CAROTENOIDS; ERYTHEMA; PSORALENS; RADIATION injuries; DNA damage; ULTRAVIOLET radiation
- Publication
Journal of Investigative Dermatology, 1988, Vol 90, Issue 1, p55
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12462564