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- Title
Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.
- Authors
Ochs-Balcom, Heather M.; Johnson, Courtney; Guertin, Kristin A.; Qin, Bo; Beeghly-Fadiel, Alicia; Camacho, Fabian; Bethea, Traci N.; Dempsey, Lauren F.; Rosenow, Will; Joslin, Charlotte E.; Myers, Evan; Moorman, Patricia G.; Harris, Holly R.; Peres, Lauren C.; Wendy Setiawan, V.; Wu, Anna H.; Rosenberg, Lynn; Schildkraut, Joellen M.; Bandera, Elisa V.
- Abstract
<bold>Background: </bold>Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race.<bold>Methods: </bold>We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models.<bold>Results: </bold>The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (ORBMI 30+= 1.62, 95% CI: 1.16, 2.26) and White women with obesity (ORBMI 30+= 1.20, 95% CI: 1.02, 2.42) compared to non-obese. Obesity was associated with higher NHGS risk in White women who never used HT (ORBMI 30+= 1.40, 95% CI: 1.08, 1.82). Higher NHGS ovarian cancer risk was observed for AA women who ever used HT (ORBMI 30+= 2.66, 95% CI: 1.15, 6.13), while in White women, there was an inverse association between recent BMI and risk of EOC and HGS in ever-HT users (EOC ORBMI 30+= 0.81, 95% CI: 0.69, 0.95, HGS ORBMI 30+= 0.73, 95% CI: 0.61, 0.88).<bold>Conclusion: </bold>Obesity contributes to NHGS EOC risk in AA and White women, but risk across racial groups studied differs by HT use and histotype.
- Subjects
OBESITY complications; BODY mass index; RESEARCH funding; OVARIAN tumors; CASE-control method; OBESITY; DISEASE complications
- Publication
British Journal of Cancer, 2022, Vol 127, Issue 11, p1983
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-022-01981-6