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- Title
Addition of an online, validated family history questionnaire to the Dutch FIT-based screening programme did not improve its diagnostic yield.
- Authors
Roos, Victorine H.; Kallenberg, Frank G. J.; van der Vlugt, Manon; Bongers, Evelien J. C.; Aalfs, Cora M.; Bossuyt, Patrick M. M.; Dekker, Evelien
- Abstract
<bold>Background: </bold>Faecal immunochemical testing (FIT) is suboptimal in detecting advanced neoplasia (AN). To increase the sensitivity and yield of a FIT-based screening programme, FIT could be combined with risk factors for AN. We evaluated the incremental yield of adding a family history questionnaire (FHQ) on colorectal cancer (CRC) and Lynch syndrome-associated tumours to the Dutch FIT-based screening programme.<bold>Methods: </bold>Six thousand screen-naive individuals, aged 59-75 years, were invited to complete a FIT (FOB-Gold, cut-off 47 µg Hb/g faeces) and a validated online FHQ. Participants with a positive FIT and/or positive FHQ, confirmed after genetic counselling, were referred for colonoscopy. Yield of detecting AN per 1000 invitees for the combined strategy was compared with the FIT-only strategy.<bold>Results: </bold>Of the 5979 invitees, 1952 (32.6%) completed the FIT only, 2379 (39.8%) completed both the FIT and FHQ and 95 (1.6%) completed the FHQ only. Addition of the FHQ to FIT-based screening resulted in one extra case of AN detected after 16 additional colonoscopies, resulting in a yield of 19.6 (95% CI, 16.4-23.5) for the combined strategy versus 19.5 (95% CI, 16.3-23.3) for the FIT-only strategy (p = 1.0).<bold>Conclusions: </bold>The addition of an FHQ to one round of FIT screening did not increase the detection of AN compared with FIT only (ClinicalTrials.gov NCT02698462).
- Subjects
NETHERLANDS; COLONOSCOPY; EARLY detection of cancer; COLORECTAL cancer; FECES; FECAL occult blood tests
- Publication
British Journal of Cancer, 2020, Vol 122, Issue 12, p1865
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-020-0832-8