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- Title
Increased replication of HTLV-I in HTLV-I-associated myelopathy.
- Authors
Yoshida, Mitsuaki; Osame, Mitsuhiro; Kawai, Hisaomi; Toita, Masami; Kuwasaki, Nanako; Nishida, Yoshihiko; Hiraki, Yukako; Takahashi, Kouichi; Nomura, Koichiro; Sonoda, Shunro; Eiraku, Nobutaka; Ijichi, Shinji; Usuku, Koichiro
- Abstract
To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymtopmatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV-I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA, indicating adult T-cell leukemia.
- Publication
Annals of Neurology, 1989, Vol 26, Issue 3, p331
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410260304