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- Title
Hearing function after intratympanic application of gadolinium-based contrast agent: A long-term evaluation.
- Authors
Louza, Julia; Krause, Eike; Gürkov, Robert
- Abstract
<bold>Objectives/hypothesis: </bold>The aim of this study was to evaluate the long-term influence of intratympanic gadolinium-based contrast agent on hearing function in patients with possible Ménière's disease and normal auditory thresholds who were undergoing locally enhanced magnetic resonance imaging scans.<bold>Study Design: </bold>Prospective observational cohort study in a tertiary referral university hospital ear, nose, and throat department.<bold>Methods: </bold>Between 2009 and 2012, 17 patients with possible or probable Ménière's disease and a four-tone pure-tone average baseline of <25 dB were recruited for our study. Before undergoing intratympanic injection of gadolinium-based contrast agent, all patients underwent a complete audiological evaluation. The study population was then invited back after at least 6 months postinjection for a follow-up auditory evaluation. This consisted of comprehensive clinical and audiological tests on both sides and were evaluated according to the ototoxicity guidelines.<bold>Results: </bold>A long-term evaluation of our study group revealed no significant difference in the air-conduction pure-tone average. Furthermore, no statistical difference at individual frequencies compared to baseline was found. There was no evidence of ototoxicity in the injected ear.<bold>Conclusions: </bold>Long-term hearing function assessment after intratympanic application of gadolinium-based agent showed no evidence of ototoxicity. The use of intratympanic gadolinium-based agent in the diagnosis of Ménièrés disease is currently a helpful tool, and seems to be a safe method, especially with regard to auditory function.<bold>Level Of Evidence: </bold>4.
- Subjects
AUDIOMETRY; HEARING; LONGITUDINAL method; MENIERE'S disease; CONTRAST media
- Publication
Laryngoscope, 2015, Vol 125, Issue 10, p2366
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.25259