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- Title
The role of elective neck dissection in early stage buccal cancer.
- Authors
Huang, Shiang‐Fu; Tung‐Chieh Chang, Joseph; Liao, Chun‐Ta; Kang, Chung‐Jan; Lin, Chien‐Yu; Fan, Kang‐Hsing; Wang, Hung‐Ming; Chen, I‐How
- Abstract
Objectives/Hypothesis The benefits of elective neck dissection (END) in early-stage tongue cancer have been widely discussed but are still controversial regarding early-stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early-stage buccal cancer in an areca-quid endemic area. Study Design Retrospective case-control study. Methods One hundred seventy-three cT1-2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high-risk patients. Results The 5-year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively ( P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions ( P = .053). The 5-year neck control rate rates ( P = .001) and disease-free survival rates ( P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS ( P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety-four percent of SPTs were located within the oral cavity. Conclusions END was suggested in T1-T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow-up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS. Level of Evidence 4 Laryngoscope, 125:128-133, 2015
- Subjects
HEAD &; neck cancer treatment; DISSECTION; NECK dissection; SECONDARY primary cancer; CANCER chemotherapy
- Publication
Laryngoscope, 2015, Vol 125, Issue 1, p128
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.24840