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- Title
β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution.
- Authors
Lekva, Tove; Bollerslev, Jens; Godang, Kristin; Paasche Roland, Marie Cecilie; Friis, Camilla Margrethe; Voldner, Nanna; Henriksen, Tore; Ueland, Thor
- Abstract
Context: Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes. Objective: The aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum. Design: This follow-up study included 300 consecutively enrolled women from a previous population-based cohort study. The participants underwent oral glucose tolerance test under pregnancy and in the follow-up study, in addition to dual-energy X-ray absorptiometry in the follow-up study. Results: Fifty-two women (17.7%) were found to have GDM in pregnancy with an odds ratio of 4.8 developing prediabetes 5 years later. b-cell function, but not insulin resistance or sensitivity, was reduced in the follow-up study after adjusting for known risk factors. Furthermore, visceral fat content at follow-up was increased in GDM women compared to non-GDM women, and the b-cell function declined with increasing visceral fat in both groups but was more pronounced in the women with previous GDM. Conclusions: Women with GDM are at increased risk of developing prediabetes and have a decreased b-cell function 5 years post-partum that is associated with increased visceral fat mass.
- Subjects
GESTATIONAL diabetes; CELL physiology; ADIPOSE tissue physiology; VISCERA physiology; GLUCOSE metabolism; PREDIABETIC state; DISEASE risk factors
- Publication
European Journal of Endocrinology, 2015, Vol 173, Issue 1, p63
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-15-0153