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- Title
ENDOJEN BİR ANKSİYOLİTİK OLARAK ATRİAL NATRİÜRETİK PEPTİD.
- Authors
Yıldırım, Ejder Akgün; Eşsizoğlu, Altan; Mengi, Murat; Yurdakoş, Ertan
- Abstract
Neuropeptides are gaining increasing significance in describing the psychophysiology of the cent-ral nervous system. Atrial natriuretic peptide (ANP), a hormone isolated from atrial myocytes and known as a hemodynamic hormone, has a very extensive extra-cardiac distribution. In the central nervous system, ANP binding sites and ANP immunoreactivity have found to be widespread in sep-tum, hypothalamic nuclei, locus ceruleus, olfactory nuclei, limbic cortex, hippocampus, amygdale and diencephalic limbic conduction pathways. It has been shown that ANP has a decreasing func-tion of negative effects of stress hemodynamically and emotionally in stress condition It has been shown that under stress conditions ANP has an inhibitory role against the negative hemodynamic and emotional effects of stress It has been shown that in stress conditions ANP decreases the ne-gative hemodynamic and emotional effects of stress. Asserted to have opposing effects against corticotrophin-releasing factors as neuromodulators, ANP's activity in anxiety has gained signifi-cance for last two decades. In the studies performed in rodents, it was reported that intracerebro-ventricular (ICV) administration of ANP showed anxiolytic like effects, in elevated plus maze test, open-field test and social interaction tests. In addition to animal experiments, the inhibitor effects of ANP on sympathetic activation in panic attacks induced by either lactate or CCK-4 has been ob-served in limited clinical trials. It is hypothesized that ANP may be an endogenous antistressor/anxiolytic agent given its effects on the stress response. In this article, biochemical and pharmacologic features of ANP will be desc-ribed, followed by a psychophysiological and psychopharmacologic discussion on its functions on the nerve system and a further discussion of anxiolytic activity of ANP.
- Subjects
ATRIAL natriuretic peptides; TRANQUILIZING drugs; ANXIETY treatment; MUSCLE cells; LOCUS coeruleus; HEMODYNAMICS
- Publication
Yeni Symposium, 2012, Vol 50, Issue 1, p3
- ISSN
1300-8773
- Publication type
Article