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- Title
Strigolactones--a novel class of phytohormones as anti-cancer agents.
- Authors
HASAN, Mohammed Nihal; RAZVI, Syed S. I.; KUERBAN, Abudukadeer; BALAMASH, Khadijah Saeed; AL-BISHRI, Widad M.; ABULNAJA, Khalid Omar; CHOUDHRY, Hani; KHAN, Jehan A.; MOSELHY, Said Salama; Zamzami Ma; KUMOSANI, Taha A.; AL-MALKI, Abdulrahman L.; ALHOSIN, Mahmoud; Tadao ASAMI
- Abstract
Chemotherapy shows some promising results in the inhibition of cancer, but resistance to chemotherapy and its severe side effects may occur in due course, resulting in only restricted and narrow benefits. Therefore, there is a pressing need to find alternative chemotherapeutic drugs for combating cancers. Plants have been used since ages in medicine, and by the dawn of 19th century, various potent and promising anti-cancer products have been derived from plants. Strigolactones (SLs) are a novel class of phytohormones involved in regulating the branching of shoots. Recently, many novel synthesized SL analogues have been found to be effective against solid and non-solid tumours. These hormones have been reported to have a unique mechanism of inhibiting cancer cells by lowering their viability and promoting apoptosis and cell death at micromolar concentrations. Therefore, synthetic SL analogues could be future potent anti-cancer drug candidates. Further research is needed to identify and deduce the significance of these synthetic SL analogues.
- Subjects
STRIGOLACTONES; PLANT hormones; APOPTOSIS; CANCER cells; HYDROXYLATION
- Publication
Journal of Pesticide Science, 2018, Vol 43, Issue 3, p168
- ISSN
1348-589X
- Publication type
Article
- DOI
10.1584/jpestics.D17-090