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- Title
Alterações na bioquímica hepática em cães com leptospirose aguda determinada por amostras do sorogrupo Icterohaemorrhagiae.
- Authors
Varges, Isabel Maria Alexandre FreireI Renato; Lilenbaum, Walter
- Abstract
One hundred and twenty serum samples obtained from dogs with specific titres (⩾100) against Leptospira spp. serovar Icterohaemorrhagiae were tested in order to determine the enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamaglutamyltransferase (GGT), as well as of the total cholesterol, triglycerides, total protein, albumin, globulins and total, direct and indirect bilirubins serum concentrations. Thirty four animals free from clinical signs with the same age of the tested group were used as control group and submitted to the same biochemical tests. The animals with titres ⩾200 showed increased ALP activity and greater direct bilirubin concentration when compared to the control group and also to the group of dogs with titres <200 (P<0.05). A clear correlation was observed between hepatic damage, without hepatocellular necrosis, and specific seroreactivity for leptospirosis caused by serogroup Icterohaemorrhagiae.
- Subjects
ENZYMATIC analysis; DOG physiology; LEPTOSPIROSIS in animals; BIOMARKERS; ANALYTICAL biochemistry; HEPATIC coma; SPIROCHAETOSIS; SERUM; LEPTOSPIRA
- Publication
Ciência Rural, 2008, Vol 38, Issue 9, p2630
- ISSN
0103-8478
- Publication type
Article
- DOI
10.1590/S0103-84782008005000020