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- Title
Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India.
- Authors
Ghosh, Sudakshina; Bankura, Biswabandhu; Ghosh, Soumee; Saha, Makhan Lal; Pattanayak, Arup Kumar; Ghatak, Souvik; Guha, Manalee; Nachimuthu, Senthil Kumar; Panda, Chinmoy Kumar; Maji, Suvendu; Chakraborty, Subrata; Maity, Biswanath; Das, Madhusudan
- Abstract
<bold>Background: </bold>Gastric cancer (GC) is one of the most frequently diagnosed digestive tract cancers and carries a high risk of mortality. Acetaldehyde (AA), a carcinogenic intermediate of ethanol metabolism contributes to the risk of GC. The accumulation of AA largely depends on the activity of the major metabolic enzymes, alcohol dehydrogenase and aldehyde dehydrogenase encoded by the ADH (ADH1 gene cluster: ADH1A, ADH1B and ADH1C) and ALDH2 genes, respectively. This study aimed to evaluate the association between genetic variants in these genes and GC risk in West Bengal, India.<bold>Methods: </bold>We enrolled 105 GC patients (cases), and their corresponding sex, age and ethnicity was matched to 108 normal individuals (controls). Genotyping for ADH1A (rs1230025), ADH1B (rs3811802, rs1229982, rs1229984, rs6413413, rs4147536, rs2066702 and rs17033), ADH1C (rs698) and ALDH2 (rs886205, rs968529, rs16941667 and rs671) was performed using DNA sequencing and RFLP.<bold>Results: </bold>Genotype and allele frequency analysis of these SNPs revealed that G allele of rs17033 is a risk allele (A vs G: OR = 3.67, 95% CI = 1.54-8.75, p = 0.002) for GC. Significant association was also observed between rs671 and incidence of GC (p = 0.003). Moreover, smokers having the Lys allele of rs671 had a 7-fold increased risk of acquiring the disease (OR = 7.58, 95% CI = 1.34-42.78, p = 0.009).<bold>Conclusion: </bold>In conclusion, rs17033 of ADH1B and rs671 of ALDH2 SNPs were associated with GC risk and smoking habit may further modify the effect of rs671. Conversely, rs4147536 of ADH1B might have a protective role in our study population. Additional studies with a larger patient population are needed to confirm our results.
- Subjects
WEST Bengal (India); INDIA; STOMACH cancer risk factors; STOMACH cancer; GENETIC polymorphisms; ALCOHOL dehydrogenase; GENETICS; ALLELES; DISEASE susceptibility; GENES; HELICOBACTER diseases; HELICOBACTER pylori; RESEARCH funding; STOMACH tumors; RELATIVE medical risk; CASE-control method; KAPLAN-Meier estimator; ODDS ratio; GENOTYPES; DISEASE complications
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-017-3713-7