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- Title
Structural insight into mammalian sialyltransferases.
- Authors
Rao, Francesco V.; Rich, Jamie R.; Rakić, Bojana; Buddai, Sai; Schwartz, Marc F.; Johnson, Karl; Bowe, Caryn; Wakarchuk, Warren W.; DeFrees, Shawn; Withers, Stephen G.; Strynadka, Natalie C. J.
- Abstract
Sialic acid is the most abundant terminal monosaccharide on mammalian cell surface glycoconjugates. The crystal structures of a mammalian sialyltransferase, that of porcine ST3Gal-I, in the apo form and bound to analogues of the donor and acceptor substrate are now described, providing insights into the catalytic mechanism and for inhibitor design.
- Subjects
SIALIC acids; GLYCOCONJUGATES; MONOSACCHARIDES; GLYCOSYLATION; GLYCOPROTEINS; LABORATORY swine
- Publication
Nature Structural & Molecular Biology, 2009, Vol 16, Issue 11, p1186
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.1685