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- Title
Smart Wearable Patches Using Light‐Controlled Activation and Delivery of Photoswitchable Antimicrobial Peptides.
- Authors
Kalyvas, John T.; Facal Marina, Paula; Stachura, Damian L.; Horsley, John R.; Abell, Andrew D.
- Abstract
A novel strategy to treat Staphylococcus aureus (S. aureus) skin infections is presented, where UV light is used to facilitate concomitant light‐controlled activation and delivery of an antimicrobial therapeutic agent. Specifically, a new photoswitchable gramicidin S analogue was immobilized onto a polymeric wearable patch via a photocleavable linker that undergoes photolysis at the same wavelength of light required for activation of the peptide. Unlike toxic gramicidin S, the liberated active photoswitchable peptide exhibits antimicrobial activity against S. aureus while being ostensibly non‐haemolytic to red blood cells. Moreover, irradiation with visible light switches off the antimicrobial properties of the peptide within seconds, presenting an ideal strategy to regulate antibiotic activity for localized bacterial infections with the potential to mitigate resistance.
- Subjects
ANTIMICROBIAL peptides; PEPTIDE antibiotics; PEPTIDES; ERYTHROCYTES; SKIN infections; BACTERIAL diseases
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 46, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202301487