We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency‐Reversing Agents.
- Authors
Yanagihara, Mizushi; Kishimoto, Naoki; Nakahara, Kanae; Abe, Towa; Miura, Satoshi; Lin, Bangzhong; Fumimoto, Megumi; Haruta, Junichi; Misumi, Shogo; Arisawa, Mitsuhiro; Murai, Kenichi
- Abstract
Structurally simplified analogues of ansellone A, in which the decalin skeleton is replaced with a lipophilic chain, were prepared and their HIV latency‐reversing activities biologically evaluated. In particular, two analogues bearing ether and alkenyl side chains, respectively, showed comparable activities to that of ansellone A. Each of the simplified compounds was easily synthesized using Prins cyclisation chemistry.
- Subjects
BIOSYNTHESIS; RING formation (Chemistry); DECAHYDRONAPHTHALENE; PHARMACEUTICAL chemistry; NATURAL products
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 44, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300677