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- Title
Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes.
- Authors
Yaping Zhao; Chunmei Zhang; Xiaohui Chen; Chunlin Gao; Chenbo Ji; Fukun Chen; Chun Zhu; Jingai Zhu; Jialin Wang; Lingmei Qian; Xirong Guo
- Abstract
NYGGF4 is a recently discovered gene that is involved in obesity-associated insulin resistance. The exact mechanism by which NYGGF4 induces insulin resistance has not yet been fully elucidated. In this study, we demonstrated that the overexpression of NYGGF4 in 3T3-L1 adipocytes decreased mitochondrial mass, mitochondrial DNA, and intracellular ATP synthesis. In addition, NYGGF4 overexpression also led to an imbalance of the mitochondrial dynamics and excess intracellular ROS production. Collectively, our results indicated that the overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance.
- Subjects
MITOCHONDRIAL pathology; INSULIN resistance; FAT cells; MITOCHONDRIAL DNA; OBESITY; ADENOSINE triphosphate; CHEMICAL synthesis
- Publication
Molecular & Cellular Biochemistry, 2010, Vol 340, Issue 1/2, p41
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-010-0398-5