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- Title
The Risk Factors of Severe Acute Kidney Injury Induced by Cisplatin.
- Authors
Mizuno, Tomohiro; Ishikawa, Kazuhiro; Sato, Waichi; Koike, Takahiro; Kushida, Mayu; Miyagawa, Yasuhiro; Yamada, Kiyofumi; Hirata, Sumio; Imai, Enyu; Noda, Yukihiro
- Abstract
Objectives: We reported that the KDIGO (Kidney Disease: Improving Global Outcomes) criteria could stratify the risk of mortality in acute kidney injury (AKI) caused by cisplatin. The purpose of this study was to investigate risk factors of severe cisplatin-induced AKI (CIA). Methods: From January 2006 to December 2012, we identified Japanese cancer patients who were treated with cisplatin as a first-line chemotherapy at Nagoya University Hospital. Serum creatinine levels were used to define CIA. Results: We evaluated 1,721 patients treated with cisplatin. In multivariable analysis, cisplatin dosages/m2 [odds ratio (OR) 1.019] or diagnosis of cancer stage 4 (OR 1.797) were risk factors of moderate CIA. History of diabetes mellitus (OR 3.454), history of cardiovascular disease (OR 3.612) or diagnosis of cancer stage 4 (OR 2.610) were risk factors of severe CIA. Conclusions: Diabetes mellitus, cardiovascular disease and advanced cancer increased the risk of severe CIA. As severe CIA shortens the survival period, we should consider whether the use of cisplatin benefits these patients. © 2013 S. Karger AG, Basel
- Subjects
JAPAN; ACADEMIC medical centers; CARDIOVASCULAR diseases; CHI-squared test; CISPLATIN; CONFIDENCE intervals; DIABETES; EPIDEMIOLOGY; KIDNEY diseases; MEDICAL records; MULTIVARIATE analysis; RISK assessment; DATA analysis; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test
- Publication
Oncology, 2013, Vol 85, Issue 6, p364
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000356587