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- Title
Phase II Study of a 3-Week Schedule of Irinotecan Combined with Cisplatin in Previously Untreated Extensive-Stage Small-Cell Lung Cancer.
- Authors
Jeong Eun Lee; Hee Sun Park; Sung Soo Jung; Ju Ock Kim; Sun Young Kim
- Abstract
Background: Irinotecan has been introduced to improve the treatment of small-cell lung cancer (SCLC). We conducted a trial involving a 3-week schedule of irinotecan combined with cisplatin (IP) to validate the efficacy and toxicity of this regimen in patients with previously untreated extensive-stage SCLC (ES-SCLC). Patients and Methods: Twenty-eight patients with previously untreated ES-SCLC were enrolled in the study between January 2003 and December 2005. Irinotecan 60 mg/m2 was administered intravenously on days 1 and 8 in combination with cisplatin 60 mg/m2 on day 1 every 21 days. Results: Twenty-eight patients were followed until July 2007. The median follow-up time was 15.6 months. The actual dose intensities (DIs) of cisplatin and irinotecan were 97.7 and 92.2%, respectively. Among the 28 ES-SCLC patients, the objective response rate was 89.3% (25 patients). The major grade 3/4 hematological toxicity was neutropenia (26.9% of cycles). Grade 3/4 non-hematological toxicities were rare. The median progression-free and overall survival times were 8.7 and 16.5 months, with a 1-year survival rate of 66.6% and 2-year survival rate of 22.2%. Conclusion: The 3-week schedule of IP was feasible and showed a high DI of irinotecan and decreased toxicity. Copyright © 2008 S. Karger AG, Basel
- Subjects
CISPLATIN; SMALL cell lung cancer; CANCER treatment; THERAPEUTICS; PHARMACODYNAMICS
- Publication
Oncology, 2007, Vol 73, Issue 1/2, p76
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000120632