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- Title
Aspergillus arthritis and organ transplantation.
- Authors
Figuères, Marie-Lucile; Cantarovich, Diego; Tattevin, Pierre; Le Pogamp, Patrick; Polard, Jean-Louis; Stock, Nathalie; Blancho, Gilles
- Abstract
We report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. The whole diagnostic work-up including synovial and bone biopsies remained negative. After inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed Aspergillus fumigatus hyphae. Treatment with voriconazole along with hip replacement led to complete recovery. However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection. Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.
- Subjects
COMPLICATIONS from organ transplantation; ASPERGILLUS fumigatus; ARTHRITIS; KIDNEY transplantation; PANCREAS transplantation; IMMUNOSUPPRESSION; INFECTIOUS arthritis; BONE biopsy
- Publication
Nephrology Dialysis Transplantation, 2012, Vol 5, Issue 3, p237
- ISSN
0931-0509
- Publication type
Article