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- Title
SYNERGISTIC POTENTIAL OF PINUS NIGRA J.F. ARNOLD AND THYMUS L. ESSENTIAL OILS AGAINST DIFFERENT HUMAN PATHOGENS.
- Authors
KAHYA, Sümeyye Elif; KARADAĞ, Ayşe Esra; DEMİRCİ, Betül; BAŞER, K. Hüsnü Can; DEMİRCİ, Fatih
- Abstract
In this study, it is aimed to evaluate the in vitro antimicrobial effects of Pinus nigra J.F. Arnold and Thymus serpyllum L., T. capitatus Hoffmans. & Link, and T. vulgaris L. essential oils individually and in combination. The composition of the commercial essential oils was confirmed using by simultaneous Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography/Flame Ionization Detector (GC/FID) analyses. The major component of P. nigra essential oil was α-pinene (73.8 %), while the major constiutents of T. capitatus, T. serpyllum, T. vulgaris oils were carvacrol (65.8%), geraniol (19.3%) and thymol (31.1%), respectively. In vitro antimicrobial evaluation of commercial essential oils against Streptococcus aureus, Moraxella catarrhalis, Escherichia coli were performed using a broth microdilution assay. The synergistic or antangonistic effects of P. nigra and Thymus sp. essential oils were evaluated using the checkherboard method, where the fractional inhibitory concentration (FIC) and fractional inhibitory concentration index (FICI) values were calculated. According to the initial results, the FICI of P. nigra + T. capitatus essential oil combinations against M. catarrhalis showed synergic effect, while P. nigra +T. serpyllum oil combinations showed antagonism. To the best of our knowledge, this is the first study for P. nigra + Thymus essential oil combinations against selected human pathogenic microorganisms.
- Subjects
ESSENTIAL oils; AUSTRIAN pine; THYMUS; FLAME ionization detectors; GAS chromatography/Mass spectrometry (GC-MS); TERPENES
- Publication
Journal of Research in Pharmacy, 2023, Vol 27, p112
- ISSN
2630-6344
- Publication type
Article