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- Title
Association between anticholinergic burden and dementia in UK Biobank.
- Authors
Mur, Jure; Russ, Tom C.; Cox, Simon R.; Marioni, Riccardo E.; Muniz-Terrera, Graciela
- Abstract
Background: Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs. Methods: Using Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia inUK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775). Results:AChB according to most anticholinergic scales (standardized odds ratio range: 1.027-1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068-1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics. Discussion: The heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.
- Subjects
UNITED Kingdom; PROPORTIONAL hazards models; DEMENTIA; DISEASE risk factors
- Publication
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, Vol 8, Issue 1, p1
- ISSN
2352-8737
- Publication type
Article
- DOI
10.1002/trc2.12290