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- Title
Flow Synthesis of Nature-Inspired Mitochondria-Targeted Phenolic Derivatives as Potential Neuroprotective Agents.
- Authors
Pecora, Desirée; Annunziata, Francesca; Pegurri, Sergio; Picone, Pasquale; Pinto, Andrea; Nuzzo, Domenico; Tamborini, Lucia
- Abstract
A series of phenolic derivatives designed to selectively target mitochondria were synthesized under flow conditions starting from natural phenolic acids. The two-step continuous flow protocol, performed in Cyrene, a bioavailable dipolar aprotic solvent, allowed the isolation of the MITO compounds in moderate to good yields. The MITO compounds obtained, as a first step, were tested for their safety by cell viability analysis. The cytocompatible dose, in human neuronal cell line SH-SH5Y, depends on the type of compound and the non-toxic dose is between 3.5 and 125 µM. Among the seven MITO compounds synthesized, two of them have shown interesting performances, being able to protect mitochondria from oxidative insult.
- Subjects
NEUROPROTECTIVE agents; APROTIC solvents; PHENOLIC acids; CELL survival; CELL analysis
- Publication
Antioxidants, 2022, Vol 11, Issue 11, p2160
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11112160