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- Title
梭甲基化棉短绒止血纱布的制备及性 .
- Authors
柳小军; 徐玉菌; 刘康博; 周静; 韩颖; 熊明; 田源
- Abstract
BACKGROUND: At present, cotton lint and its modified products have been widely concerned in clean ing water or oil pollution, but the preparation of cotton lint for hemostatic gauze has not been reported. OBJECTIVE: To prepare a kind of carboxymethylated cotton I inters hemostatic gauze by modifying cotton I inters gauze and characterize it. METHODS: Carboxymethylated cott on linters cotton gauze was prepared by chemical modification. Infrared spectrometer, scanning electron microscope and X-ray diffractometer were used to characterize the morphology and structure of cotton linter gauze group (raw material), carboxymethylated cotton linter hemostatic gauze (experimental group) and absorbable hemostatic gauze (control group). The physical and chemical indexes were measured by water absorption, mechanical properties, gelation rate and solubi lity. The hemostatic performance was tested by measuring whole blood coagulation time. At last, the cytocompat ibility of gauze in the experimental group was evaluated by cytotoxicity test in vitro. RESULTS AND CONCLUSION: (1) The result of infrared spectrum showed that carboxymethylation occurred in the gauze from experimental group, The hydrophil ic carboxymethyl group was introduced into the fiber structure. X-ray diffraction results showed that compared with the raw material group, the crystal phase of the experimental and the control groups was incomplete with the crystal linity decreased. (2) Scanning electron microscope result showed that the fibers of the raw material group were straight and tightly arranged. In the experimental group, the fiber braiding mode was not changed, but the arrangement was loose, the fiber diameter was increased, and the surface roughness was increased. In the control group, the fiber had a unique weavi ng mode; the fiber surface was long and thin, smooth and the texture was clear. (3) There was no significant difference in porosity among the three groups (P > 0.05 ). The water absorption rate of the experimental group was higher than t hat of the raw material group (P < 0.05) and lower than that of t he control group (P < 0.05). (4) Both the experimental group and the control group formed gel within 30 seconds after water absorption, and completely dissolved within 1 hour. (5) The tensile strength of the experimental group was lower than that of the raw material group (P < 0.05), but there was no significant difference between the experimental and the control groups (P > 0.05). The fracture elongation of the experimental group was higher than that of the raw material group (P < 0.05) and lower t han that of the control group (P < 0.05). (6) The blood coagulation ti me in the experimental group was shorter than that in the raw material group (P < 0.05), while it did not differ from the control group significantly (P > 0.05 ), indicating that the gauze in the experimental group had good cytocompatibility. (7) The results suggested that carboxymethylated cotton !inters hemostatic gauze presented good physical and chemical properties, hemostatic properties and cel lular compatibility.
- Subjects
SCANNING electron microscopes; OIL spills; IR spectrometers; EXPERIMENTAL groups; BLOOD coagulation; BRAIDED structures; COTTON fibers; COTTON textiles
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2022, Vol 26, Issue 16, p2593
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2022.243