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- Title
Examining the Association between Patient-Reported Symptoms of Attention and Memory Dysfunction with Objective Cognitive Performance: A Latent Regression Rasch Model Approach.
- Authors
Yuelin Li; Root, James C.; Atkinson, Thomas M.; Ahles, Tim A.
- Abstract
Objective. Patient-reported cognition generally exhibits poor concordance with objectively assessed cognitive performance. In this article, we introduce latent regression Rasch modeling and provide a step-by-step tutorial for applying Rasch methods as an alternative to traditional correlation to better clarify the relationship of self-report and objective cognitive performance. An example analysis using these methods is also included. Method. Introduction to latent regression Rasch modeling is provided together with a tutorial on implementing it using the JAGS programming language for the Bayesian posterior parameter estimates. In an example analysis, data from a longitudinal neurocognitive outcomes study of 132 breast cancer patients and 45 non-cancer matched controls that included self-report and objective performancemeasures pre- and post-treatment were analyzed using both conventional and latent regression Raschmodel approaches. Results. Consistent with previous research, conventional analysis and correlations between neurocognitive decline and self-reported problemswere generally near zero. In contrast, application of latent regression Rasch modeling found statistically reliable associations between objective attention and processing speed measures with self-reported Attention and Memory scores. Conclusions. Latent regression Rasch modeling, together with correlation of specific self-reported cognitive domains with neurocognitivemeasures, helps to clarify the relationship of self-report with objective performance. While themajority of patients attribute their cognitive difficulties to memory decline, the Rashmodeling suggests the importance of processing speed and initial learning. To encourage the use of thismethod, a step-by-step guide and programming language for implementation is provided. Implications of this method in cognitive outcomes research are discussed.
- Subjects
ATTENTION-deficit hyperactivity disorder; MEMORY disorders; COGNITIVE ability; SELF-evaluation; COGNITION disorders
- Publication
Archives of Clinical Neuropsychology, 2016, Vol 31, Issue 4, p365
- ISSN
0887-6177
- Publication type
Article
- DOI
10.1093/arclin/acw017