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- Title
Cognitive Reserve Protects Against Apathy in Individuals with Human Immunodeficiency Virus.
- Authors
Shapiro, Miriam E.; Mahoney, Jeannette R.; Peyser, Deena; Zingman, Barry S.; Verghese, Joe
- Abstract
Apathy is associated with impaired neuropsychological functioning in individuals with HIV. While cognitive reserve (CR) delays neurocognitive decline, CR's relationship with apathy has never been studied. We examined CR's association with apathy in 116 HIV-positive individuals recruited from an urban AIDS center and assessed whether this relationship is moderated by age and/or disease severity. Participants completed the Wechsler Test of Adult Reading and Apathy Evaluation Scale. A CR-composite, combining years of education and word-reading ability, significantly predicted apathy (t = −2.37, p = .02). CR's relationship with apathy was not moderated by age, but participants with nadir CD4 levels ≤200 demonstrated a stronger association (t = −3.25, p = .002) than those with nadir CD4 levels > 200 (t = −0.61, p = .55). These findings suggest a protective effect of CR against apathy in HIV-infected individuals across the age span, particularly after a certain threshold of disease severity.
- Subjects
COGNITION research; APATHY; HIV infections &; psychology; NEUROPSYCHOLOGY; COGNITION disorders; PSYCHOLOGY of HIV-positive persons; AIDS
- Publication
Archives of Clinical Neuropsychology, 2014, Vol 29, Issue 1, p110
- ISSN
0887-6177
- Publication type
Article
- DOI
10.1093/arclin/act071