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- Title
Responsiveness of the generic EQ-5D summary measure compared to the disease-specific EORTC QLQ C-30.
- Authors
Krabbe, Paul F. M.; Peerenboom, Lonneke; Langenhoff, Barbara S.; Ruers, Theo J. M.
- Abstract
<bold>Introduction: </bold>We investigated whether the sensitivity of the generic health-related quality of life (HRQoL) EQ-5D summary measure (or index) to detect changes over time in a clinical setting is comparable with that of a disease-specific HRQoL questionnaire.<bold>Methods: </bold>Patients with liver metastases (n = 75) filled out the five domains of the EQ-5D self-classifier, the EQ VAS, and the EORTC QLQ C-30 (a disease-specific (cancer) HRQoL questionnaire). The HRQoL instruments were completed before intervention, and 1/2 month and 3 and 6 months after intervention. Three analyses were performed. First, the EQ-5D index (based on self-classification) was compared to the EQ VAS. Second, the EQ-5D domains were compared to corresponding EORTC QLQ C-30 scales. Third, EQ-5D index and EQ VAS were compared with the EORTC QLQ C-30 global health-status scale. Effect size was chosen as the metric of responsiveness.<bold>Results: </bold>The EQ-5D index was slightly less responsive than the EQ VAS. Overall, the responsiveness of the EQ-SD index and EQ VAS was equal to the EORTC QLQ C-30 global health-status scale.<bold>Conclusion: </bold>Despite its generic principle and the apparent crudeness of its framework, the responsiveness of the EQ-5D proved to be comparable to that of a disease-specific HRQoL questionnaire in this specific clinical setting.
- Subjects
QUALITY of life; QUESTIONNAIRES; METASTASIS; LIVER diseases; HEALTH status indicators; CLINICAL medicine
- Publication
Quality of Life Research, 2004, Vol 13, Issue 7, p1247
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1023/B:QURE.0000037498.00754.b8