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- Title
Interaction patterns of brain activity across space and frequency in obsessive-compulsive disorder.
- Authors
Katsushige Watanabe; Yasushi Okamura; Hiromi Kamo; Ayako Isoo; Sumito Sato; Makoto Taniguchi
- Abstract
Objectives: Despite available pharmacological and psychotherapeutic treatments about 10% of obsessive-compulsive disorder (OCD) patients remain severe, treatment-refractory. For some of these patients deep brain stimulation (DBS) offers an appropriate treatment method. In hopes of identifying better treatment options such as DBS, many attempts have been made to clarify pathological brain mechanisms, but neurophysiological measures have not been systematically examined yet. To address this question, the aim of the present study was to search for specific functional correlates cross brain region/frequency interactions in OCD patients. Methods: Routine scalp-EEG (19 electrodes) was recorded in ten OCD patients and ten healthy controls matched for age, while they were at rest with eyes closed. The investigation compares current source density measures of patients with OCD to the control group by using the techniques of low-resolution brain electromagnetic tomography (LORETA; Pascual-Marqui, et al, 1994). We also used the functional independent component analysis (fICA) to examine the interaction patterns of brain activity across region and frequency in the resting state networks by comparing between OCD patients and control subjects (Pascual- Marqui, et al, 2011). Results: The findings of the current source density measure indicated that OCD patients were characterized by significantly higher activities in the following three regions, compared to control subjects. 1) In the delta, theta and alpha bands in the frontotemporal region, 2) in the alpha and beta bands in the cingulate and 3) in the theta, alpha and beta bands in the nucleus accumbens and the bed nucleus of the stria terminalis (BNST). Although both groups of brain utilized the common resting networks, the fICA study showed how the OCD brain used following two resting state networks differently from the healthy control brain. OCD patients have 1) excess left prefrontal (PFC) delta and reduced right PFC delta, and 2) excess left frontal alpha and reduced parieto-occipital alpha. Conclusion: The nucleus accumbens as well as adjacent nucleus BNST are suggested as feasible targets for DBS in OCD from LORETA current density measures. Although most resting state networks were common to both groups of subjects, two resting state networks (between PFC hemispheres for delta activity, between left frontal and parieto-occipital area for alpha activity) differently used in OCD brain.
- Publication
Stereotactic & Functional Neurosurgery, 2017, Vol 95, p47
- ISSN
1011-6125
- Publication type
Article