We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Off label use of lithium in the treatment of Huntington's disease: A case series.
- Authors
Danivas, Vijay; Moily, Nagaraj S.; Thimmaiah, Rohini; Muralidharan, Kesavan; Purushotham, Meera; Muthane, Uday; Jain, Sanjeev
- Abstract
Huntington's disease is characterized by choreic movements, psychiatric disorders, striatal atrophy with selective small neuronal loss, and autosomal dominant inheritance. The genetic abnormality is CAG expansion in Huntingtin gene. Newer therapeutic strategies are evolving to treat this progressive disorder. The neuroprotective agents are one such group of drugs being tried. Lithium has been used to treat Huntington's disease in the past due to its neuroprotective effects. Though the precise mechanism of action is not clear, Lithium can directly or indirectly modulate proteins involved in neuronal survival/differentiation which may account for its neuroprotective effects. We report three patients with Huntington's disease in whom Lithium prevented the progression of chorea and also helped stabilize mood.
- Subjects
THERAPEUTIC use of lithium; CHOREA; AFFECT (Psychology); HUNTINGTON disease; LITHIUM; HEALTH outcome assessment; BODY movement; TREATMENT effectiveness; OFF-label use (Drugs); PREVENTION; GENETICS
- Publication
Indian Journal of Psychiatry, 2013, Vol 55, Issue 1, p81
- ISSN
0019-5545
- Publication type
Article
- DOI
10.4103/0019-5545.105522