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- Title
A molecular tweezer antagonizes seminal amyloids and HIV infection.
- Authors
Lump, Edina; Castellano, Laura M.; Meier, Christoph; Seeliger, Janine; Erwin, Nelli; Sperlich, Benjamin; Stürzel, Christina M.; Usmani, Shariq; Hammond, Rebecca M.; von Einem, Jens; Gerold, Gisa; Kreppel, Florian; Bravo-Rodriguez, Kenny; Pietschmann, Thomas; Holmes, Veronica M.; Palesch, David; Zirafi, Onofrio; Weissman, Drew; Sowislok, Andrea; Wettig, Burkhard
- Abstract
The article discusses a study which develops the CLR01, a molecular tweezer specifically designed for lysine and arginine residues, to prevent the formation of seminal amyloid fibrils that enhance HIV infection and other sexually transmitted viruses.
- Subjects
AMYLOID beta-protein; HIV prevention; SEMEN
- Publication
eLife, 2015, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.05397