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- Title
HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey.
- Authors
Yotsumoto, Mihoko; Ito, Yoshikazu; Hagiwara, Shotaro; Terui, Yasuhito; Nagai, Hirokazu; Ota, Yasunori; Ajisawa, Atsushi; Uehira, Tomoko; Tanuma, Junko; Ohyashiki, Kazuma; Okada, Seiji
- Abstract
There has been no comparative clinical study focused on differences in the clinical features of Epstein‑Barr virus (EBV)+ Hodgkin lymphoma (HL) between HIV‑positive and ‑negative cases. In a nationwide survey from 511 institutions in Japan, the present study investigated 16 EBV+ HIVpositive HL patients. To further clarify their characteristics in comparison with EBV+ HIVnegative HL (n=34) in the combination antiretroviral therapy era in Japan, the present study was performed. Results indicated that EBV+ HIVpositive HL frequently occurred in a younger population compared with EBV+ HIVnegative HL (P=0.0295), and that the EBV+ HIVpositive HL group was not associated with the nodular sclerosis subtype in the population who were below the age of 40. Notably, the EBV+ HIVpositive HL group had a significantly higher frequency of extra‑nodal involvement (P=0.0214), including marrow invasion. In the advanced stage, 80% of those with EBV+ HIVpositive HL did not require dose‑reduction and in the majority of cases, chemotherapy was completed. There were no significant differences in the complete remission rate (P=0.1961), overall survival (P=0.200) and progression‑free survival (P=0.245) between EBV+ HIVpositive HL (median observational period, 23.5 months) and EBV+ HIVnegative HL (median observational period, 64.5 months), suggesting that HIV positivity may not have a negative impact on the clinical outcome of EBV+ HL. Notably, standard chemotherapy is effective and tolerable for EBV+ HL, regardless of HIV infection.
- Subjects
HODGKIN'S disease; EPSTEIN-Barr virus; HIV-positive persons; JAPANESE people; RETROSPECTIVE studies; HEALTH; DISEASES
- Publication
Oncology Letters, 2018, Vol 16, Issue 3, p3923
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2018.9132