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- Title
Functionalization Strategies and Fabrication of Solvent-Cast PLLA for Bioresorbable Stents.
- Authors
Schieber, Romain; Raymond, Yago; Caparrós, Cristina; Bou, Jordi; Herrero Acero, Enrique; Guebitz, Georg M.; Canal, Cristina; Pegueroles, Marta; Perale, Giuseppe
- Abstract
Actual polymer bioresorbable stents (BRS) generate a risk of device thrombosis as a consequence of the incomplete endothelialization after stent implantation. The material-tissue interactions are not fully controlled and stent fabrication techniques do not allow personalized medical solutions. This work investigates the effect of different functionalization strategies onto solvent-cast poly(l-lactic acid) (PLLA) surfaces with the capacity to enhance surface endothelial adhesion and the fabrication of 3D printed BRS. PLLA films were obtained by solvent casting and treated thermally to increase mechanical properties. Surface functionalization was performed by oxygen plasma (OP), sodium hydroxide (SH) etching, or cutinase enzyme (ET) hydrolysis, generating hydroxyl and carboxyl groups. A higher amount of carboxyl and hydroxyl groups was determined on OP and ET compared to the SH surfaces, as determined by contact angle and X-ray photoelectron spectroscopy (XPS). Endothelial cells (ECs) adhesion and spreading was higher on OP and ET functionalized surfaces correlated with the increase of functional groups without affecting the degradation. To verify the feasibility of the approach proposed, 3D printed PLLA BRS stents were produced by the solvent-cast direct writing technique.
- Subjects
X-ray photoelectron spectroscopy; HYDROXYL group; CARBOXYL group; OXYGEN plasmas; FUNCTIONAL groups; CONTACT angle; ENDOTHELIAL cells
- Publication
Applied Sciences (2076-3417), 2021, Vol 11, Issue 4, p1478
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app11041478