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- Title
Recurrent blisters in a 6‐year‐old girl.
- Authors
Larijani, Mary; Rubin, Adam I.; Jen, Melinda
- Abstract
Although dapsone and low-dose prednisolone are usually effective in treating childhood EBA, refractory cases do exist, highlighting the need for further investigation into alternative immune-modulating therapies in children. Epidermolysis bullosa acquisita (EBA) is an acquired bullous dermatosis mediated by autoantibodies directed against collagen VII, a major component of the anchoring fibrils of the dermal-epidermal junction. Indirect immunofluorescence (IIF) revealed IgG4 antibodies at the dermal floor of salt-split skin, and enzyme-linked immunosorbent assay (ELISA) was positive for collagen VII antibodies.
- Subjects
EPIDERMOLYSIS bullosa; BULLOUS pemphigoid; IMMUNOMODULATORS; BLISTERS
- Publication
Pediatric Dermatology, 2021, Vol 38, Issue 3, p673
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.14582