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- Title
Atypical IgA/IgG Pemphigus Involving the Skin, Oral Mucosa, and Colon in a Child: A Novel Variant of IgA Pemphigus?
- Authors
Bruckner, Anna L.; Fitzpatrick, James E.; Hashimoto, Takashi; Weston, William L.; Morelli, Joseph G.
- Abstract
Immune-mediated blistering diseases are rare in childhood, with the subset of IgA pemphigus being extremely uncommon. A child with a bullous disorder of the oral mucosa, skin, and colon is reported because of the unusual nature of the clinical and laboratory findings. Immunofluorescence studies demonstrated both intercellular epidermal and basement membrane zone deposition of IgA and IgG antibodies, as well as intercellular colonic deposition of IgA antibodies. IgA and IgG ELISA tests were positive for desmoglein 3 as the intercellular epidermal antigen. The generation of multiple antibodies against several potential antigenic targets suggests epitope spreading may play a role in this disease. We believe this represents a novel variant of IgA pemphigus.
- Subjects
IMMUNOGLOBULIN A; PEMPHIGUS; ORAL mucosa; ANTIGENS; IMMUNOFLUORESCENCE; ENZYME-linked immunosorbent assay
- Publication
Pediatric Dermatology, 2005, Vol 22, Issue 4, p321
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/j.1525-1470.2005.22408.x