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- Title
Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders.
- Authors
Schaefer, Carola; Enning, Frank; Mueller, Juliane; Bumb, J.; Rohleder, Cathrin; Odorfer, Thorsten; Klosterkötter, Joachim; Hellmich, Martin; Koethe, Dagmar; Schmahl, Christian; Bohus, Martin; Leweke, F.
- Abstract
Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders.
- Subjects
FATTY acids; BORDERLINE personality disorder; POST-traumatic stress disorder; JUVENILE diseases; EMOTIONS; CANNABINOIDS; THERAPEUTICS
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2014, Vol 264, Issue 5, p459
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s00406-013-0470-8