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- Title
An Efficient One-Pot Green Protocol for the Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-Ones Using Recyclable Amberlyst 15 DRY as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reaction.
- Authors
Jetti, Srinivasa Rao; Verma, Divya; Jain, Shubha
- Abstract
An environmentally benign green protocol for the synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones using Amberlyst 15 DRY as a recyclable catalyst has been developed. The use of resinous, nontoxic, thermally stable, and inexpensive Amberlyst 15 DRY, as a recyclable heterogeneous catalyst, makes the process simple with negligible chemical waste. Among the various solid acid catalysts Amberlyst 15 DRY was found to be the most efficient catalyst with regard to reaction time, yield, and ease of work-up procedure.
- Subjects
PYRIMIDINE synthesis; SUBSTITUENTS (Chemistry); HETEROGENEOUS catalysts; THERMAL stability; CHEMICAL reactions; HAZARDOUS wastes; CATALYSTS recycling
- Publication
ISRN Organic Chemistry, 2012, p1
- ISSN
2090-5149
- Publication type
Article
- DOI
10.5402/2012/480989