We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Therapeutic effects of mesenchymal stem cells on renal ischemia-reperfusion injury: a matter of genetic transfer?
- Authors
Bruno, Stefania; Bussolati, Benedetta
- Abstract
Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/paracrine release of factors. The delivery of growth factors, cytokines, prostaglandins, enzymes or extracellular vesicles from mesenchymal stem cells to target cells may induce cell reprogramming and de novo expression of factors involved in tissue proliferation and repair. A recent paper showed that Wharton jelly-derived mesenchymal stem cells interact with injured renal tubular epithelial cells, inducing the expression of native and foreign hepatocyte growth factor necessary for renal repair and fibrogenesis inhibition. The genetic exchange between resident and mesenchymal stem cells, probably mediated through microvesicles, therefore appears instrumental in mesenchymal stem cell therapeutic effects.
- Subjects
MESENCHYMAL stem cells; REPERFUSION injury; GROWTH factors; CYTOKINES; PROSTAGLANDINS; ENZYMES; VESICLES (Cytology); THERAPEUTICS
- Publication
Stem Cell Research & Therapy, 2013, Vol 4, Issue 3, p1
- ISSN
1757-6512
- Publication type
Article
- DOI
10.1186/scrt205