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- Title
Mono- and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722.
- Authors
Chen, Senhua; Guo, Heng; Jiang, Minghua; Wu, Qilin; Li, Jing; Shen, Hongjie; Liu, Lan
- Abstract
Seven new xanthones, diaporthones A−G (1−7), together with 13 known analogues, including five mono- (8−14) and six dimeric xanthones (15−20), were obtained from the ascidian-derived fungus Diaporthe sp. SYSU-MS4722. Their planar structures were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HR-ESIMS). The absolute configurations of 1−7 were clearly identified by X-ray crystallographic analysis and calculation of the ECD Spectra. Compounds 15−20 showed significant anti-inflammatory activity with IC50 values between 6.3 and 8.0 μM. In addition, dimeric xanthones (15−20) showed selective cytotoxicity against T98G cell lines with IC50 values ranging from 19.5 to 78.0 μM.
- Subjects
ANTI-inflammatory agents; XANTHONE; MASS spectrometry; FUNGI; CELL lines
- Publication
Marine Drugs, 2022, Vol 20, Issue 1, p51
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20010051